The lecture, scheduled for April 28, will focus on DNA replication without the CDC7 protein. According to current knowledge, a kinase called CDC7 is essential for cell division in all studied organisms: from yeast to humans. At the molecular level, CDC7 initiates DNA replication. During the lecture, Professor Piotr Siciński will talk about his team's research verifying the above model. They generated cells and mice in which the CDC7 protein can be specifically and temporally degraded. Studies have shown that a different mechanism operates in mammalian cells that allows DNA replication without the CDC7 protein.
The lecture will be held in English.
Willingness to participate should be reported to biurojakosci@wum.edu.pl by April 28.
The number of places is limited. Participation is determined on a first-come, first-served basis.
Prof. Piotr Siciński is a 1984 graduate of MUW. He also earned his doctorate at his alma mater. In 1997, he joined the faculty of Harvard University and the Dana-Farber Cancer Institute, where he conducts research on the role of genes in cell-cycle mechanisms involved in normal cell development and in cancer formation.
Photo: https://www.dana-farber.org/; author: Sam Ogden, Copyright: All Images © Dana-Farber Cancer Institute